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For aging endurance athletes, this decline may contribute to the increased vulnerability to overuse injuries that characterizes masters-level competition

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Estrogen-related receptor alpha (ERRα) is a nuclear receptor—not directly involved in estrogen signaling—that plays a critical role in regulating: Mitochondrial biogenesis Fatty acid oxidation Glucose metabolism Oxidative phosphorylation Thermogenesis and cellular respiration It is highly expressed in energy-demanding tissues like skeletal muscle, heart, and brown fat